My first handgun was a Springfield Omega Match in 10mm, gifted to me by my father when I turned 21. It was a favorite of mine from his collection, and he didn't care to shoot it all that often, so gave it to me when I turned old enough have my own.
Shortly thereafter, I bought a .45ACP Taurus 24/7 Pro. Nice enough gun, only problems I had with it were in regards to certain ammo I tried to run through it. I eventually sold it, though.
My first revolver, second handgun purchase, was a Uberti Cattleman in .45LC. Still have it, and love to shoot it when I can scrounge up ammo at a decent cost.