When I bought my Detonics Mark VI's, and a VII, the .451 Detonics 185 grain bullet at about 1350 fps, and, the 200 grain Speer flying Ashtrays, pushed at 1200 fps, were being used by police that wanted a more powerful gun, but, was PC..
The gunsmiths advised me that they had pictures of actual shootings with the 200 grain flying ashtrays, and, that on numerous shots, the exit wounds were very large, thanks to hitting bone, and creating high speed fragments, coupled with the bullet maintaining it's velocity through the target, and exiting. They suggested that combination was an ideal round, for actual shootings, and, stopped quite well. I adopted that approach, and, never had to use the rounds on a target, other then paper. Out of the Mark VI they were the most accurate combination I've ever had in a small gun. That was late 70's early 80's, IIRC.