Personally, I wouldn't carry .410 for any sort of social work outside the house for liability purposes. One stray buckshot could kill a baby or worse, a Syrian refugee's baby. I'd stick to .45 Colt, it's not that inaccurate even from a Public Defender.
For home defense, Federal 000 Buck all night and day.
EDIT: As for mixing up the cylinder with different ammo like birdshot, buckshot, .45 Colt, slugs, etc. I think that's something that's only worth doing if you're out in the wilderness and are unsure what you might encounter and you don't want to be fumbling taking rounds out of the chamber to replace them with something else.
For defense in civilization, you're best sticking with the same thing in every chamber for consistency sake. You don't want to have a situation where a coked up dude attacks you with a knife and you pump his beer gut full of birdshot.