No. I have a Ruger P345 in the nightstand and if I ever need it in a hurry, I can't be fiddling with a holster. If the trigger is exposed, you can actually shoot a revolver while it's still in the holster. I guess you could do the same thing with a pistol but the difference is that you'll only get one shot off and then you're pistol will jam because the spent casing cannot eject itself clear of the holster. Some holsters it could, but most holsters hold the pistol a little deeper and actually cover the ejection port.
So, the answer is no, I do not have it in a holster. None of my pistols or revolvers are kept in holsters. Specificaly, leather holsters. They retain moisture, and all of us know that moisture is not a firearm's best buddy. More importantly, though, is in the event I'll ever need it in a hurry. I want something I can quickly grab, flick the safety off, and start educating someone very quickly on the hazards of breaking into my home!!