OK, time to fire up the flames. Hornady's Critical Defense ammo has received decent reviews at the least, to my knowledge. Speer's Gold Dots are same-same or close behind. Other stuff is coming out at an encouraging pace.
A PMR-30 22WMR, loaded with 25 rounds of Hornady Critical Defense 45 gr. bullets with the effective poly insert, weighs 19 ounces. By rough calculation, I could carry that gun with 100 rounds at the same total weight or less as a single 1911 loaded with eight rounds of ball ammo. Sure, I'd rather shoot one bad guy with one good round from a .45, but relative to the real world, what is most likely to happen?
A druggie might get to me despite what I could insert into him with such a gun, but generally speaking, round-after-round of noisy ammo that can cause enough hurt to stop a fight ought to be considered as an option.
Like most of us, I have all of this stuff. When there is a bump in the dark, I am likely to reach for the 1911. But after comforting range time with the PMR, it at least will be in my other hand. Lots of "bangs" should not be dissed, IMO, given the "hit" rate in most confrontations. Very few perps will continue to advance under a continuous hail of fire. Otherwise, I was taught wrong in the military.