I carried a S&W M296 Airweight Centennial in .44 Special for around ten years. Started out with the hot CorBon JHP load. When the 200 grain all copper DPX came out, I switched to those. Really, it was a fine combination and very light to carry all day. Things like the theater mass shooting pushed me in a different direction with my carry gun. I wanted better accuracy at a longer range, I wanted a bullet that would penetrate most vests, and I wanted more rounds. So I carry an HK P2000 LEM in .357 SIG now.
The ultimate big bore snubby is one of my favorite guns. Ruger Super Alaskan in .480 Ruger. Really fine revolver and not too strenuous to shoot. But OK has a "no carry over .45 caliber" rule so I've never been able to carry it around off the property.
Gregg