The .327 mag is a little low powered for hunting big game.
Out of a 4" barrel, 115 grain loads are comparable to a 9mm +P+ and 85 grain loads are pretty close to 7.62x25.
9mm +P+ ... You do know what that means, right? That means the load is beyond SAAMI limits (even +P loads), and is
unregulated. You have NO idea what pressure level the load is actually reaching.
Trying to use "9mm +P+" as a baseline is like trying to compare all cars to a "Custom Supercharged Mustang". Okay... What engine? Compression ratio? Cam grind? Stroked? Bored? Pistons? What octane fuel? Gear ratios? How has it been customized? Weight loss program? And, on, and on. But most of all: Does the driver actually know how to use the power available for the most benefit? If the operator can get the job done just as well with the lower-power (.327 or V6) version of something, what's the point of wasting energy on the "big" stuff (.44 Mag or V8)?
That Antelope expired very quickly, with a teeny little .277" hole through both lungs. No evidence of hydro-static shock. No heart shot. ...Just a little bitty hole through the lungs. If the .327 was legal, it would have been even more efficient. Antelope are so small and fragile, that all but the softest of rifle bullets just punch right through. In fact, I don't think we've ever recovered even a pistol bullet from antelope (including .357 Mag, .41 Mag, .44 Mag, and .45 Auto; hand loads and a couple rounds of SD ammo).
Like all hunting (or any use of a firearm); it's not the cartridge that matters... it's how you use it. Taking 300 yard shots with a .327 would be pretty stupid (and the same thing applies to pretty much any pistol cartridge). On the other hand, I try to get as close as I can, anyway. For me, switching from the .44 Mag Super Blackhawk to the .327 GP100 or .327 Blackhawk is nothing at all; and the cartridge is perfectly capable of providing the performance necessary for a clean kill.
If I get a chance to hunt Antelope or Deer in Utah (where it's legal) next year, one of the .327s will be my primary weapon (not the backup). And, when I get to Nawth Cackalacky (that's "North Carolina" in English), a .327 will be the primary Whitetail weapon.