Wife's preference
My wife has shot my Browning Buckmark .22, Ruger SP 101 .38/.357 S&W model 19 .38/.357 and Glock mod. 22, .40 S&W
She doesn't shoot because she wants to, She only shoots when I tell her to. She needs to be familiar with the guns so she can protect herself and back me up.
I won't count the .22, even she knows it's not the best defensive round. She tolerated the S&W Model 19 with .38 special the best. Not great with it but I wouldn't want her shooting at me. I gave the Smith to my daughter when she moved out so for now the Glock has to be her go to gun, She can handle it but doesn't really like it. When prices come down a little I intend to buy a Ruger GP-100. I'm sure she will like it.