JMHO
I have had the chance to do a little hiking and camping in Wyoming, where I have family. My choice for a long gun was my 1895 Guide Gun, I have two loads for that gun. The first is Buffalo Bores' 430gr. hardcast load that goes @ about 1870fps. over my Chrono. The Other was a 405gr. handload that gave me about 50fps. more out of the same gun. Both loads go completely through one foot of greeen Honey Locust,which is an amzingly hard, dense medium, and I believe would penetrate at least two and a half feet through any mammal, heavy bone notwithstanding.
As for a handgun load, I have two choices, the first being a 335gr. LWFN bullet over a suitable amount of H-110 that gives me 1150fps. +or- from my Ruger Blackhawk in .45 Colt, the other being a 265gr. .41 Mag at 1205fps.
I use the .41 Mag load, as I can get all 6 out of the gun and hit a pie plate at 20 yards in under 10 seconds, which, for me anyway, is fast. The .45 Colt load is all but uncontrollable trying to do the same shooting. I would rather hit an attacker 6 times with that gun than miss it 3 out of six with the other load.
That is the best medicine that I can personaly handle for such a large critter.
Several years back while hiking in northern New Mexico I came out of an aspen forest onto a High Desert Alpine field and stumbled into a group of 6, 5x6 and larger Bull Elk, they were no more than 25' from me, they were just as suprised to see me as I was them, they were NOT HAPPY with my presense
!! I was armed with both the Guide Gun stoked with my handloads and the .41 Mag. To make a long story a little less long, my feeling at the time, having a staring contest with said Elk was that I might as well have had a flyswatter!! If these animal had come at me, they would have turned me into a puddle of Goo before I could have gotten off my third round.
I do not feel embarressed to say that that was the most frightened I have ever been in my life!! Thank God that after a few seconds they decided to turn and saunter away.
I do not ever want to see Angry Elk at that distance again. I cannot imagine shaking hands with a Brownie that close.
I guess my point is that you take the most powerful weapon(s) you have and be prepared to shoot accuratly, shoot as fast as you can, and still feel woefully undergunned!
JMHO, and as always, YMMV.
Willy