I have had (but sold long ago):
Ruger KP89. Big, blocky, unergonomic, inaccurate, but 100% reliable
SIG P226. Ergonomic, fun, accurate, but not totally reliable (a surprise to me since it was a W. German made SIG)
I currently have:
CZ 75B. Perfection...Reliable, ergonomic, accurate, fun gun
CZ P01. Needs more range time to prove itself, but it looks like it is every bit the smaller version of the 75B
SIG P290RS. Love it, reliable, more accurate and comfortable to shoot than any single stack mini-9 has any right to be.
Kel Tec Pf-9. Not totally reliable, very uncomfortable to shoot, reasonably accurate.
If you are looking for a gun for both you and your wife to shoot, I will 2nd (or 3rd, or whatever) the recommendation you already got that you should look for something with adjustable backstraps or other grip options. SIG P250, SIG P320, 4th Gen Glock, S&W M&P, etc. As someone else suggested, I'm also a big fan right now of intermediate sized guns that are decent at the range and also concealable (SIG P250 Compact or P320 Compact, CZ P01/PCR, Glock 19, etc.).