Very good question for a thread OP!
I've been a handgun shooter for longer than I like to admit (since the mid 1970's).
I've owned and still own the best of the best -- Beretta, Colt, S&W, Sig, HK, Browning, Walther, etc. -- No Hi Points or Taurus here.
I have several favorite pistols and it's based on their reliability, accuracy and ergonomics.
Beretta 92 FS, BHP, Sig P220, Sig P226, HK P30 L, HK 45 C, Walther PPS.
They all run like Swiss timepieces with just regular cleaning and lubrication.
When it comes to my family's safety, I want absolute dead nuts reliability.