Confident with my 9mm, .357 Sig, .40 S&W, .38 Spl., .357 magnum, .45 ACP...
Shoot'en strait is far far more important than what exact round you have (and yes, even FMJ can do the deed fine if you are a strait shooter.)
The larger the round, the more clout, but the differience is not all that great.
And the size of the gun (and weight) also matter as for contol. Not only as for how heavy it is, but how it's shaped. Called egromonics. That matters to.
I practice so much for IDPA and some of the courses I attend that skill wise I'm not at all worried, be it 9mm, .38 or whatever. With either hand to.
Might not be real happy with a .25 auto, but I'm sure I could make even a good size .380, like a Sig 232 or 9x18 Makarov, do the deed.
I carry a Glock 27 cuase I got it cheep. It has night sights and NY-1 trigger, as does my Glock 26, Glock 19, Glock 32, and Glock 23. Only my IDPA state Glock 17 has a 5 lb regular trigger (and I might just move it up to a NY-1 to.)
But I have wheelguns, and 1911s, and Sig SA/DAs, and other toys and I know well how to use them. I grew up on Colt 'O' and Smith 'K' frames.
Don't spend so much time on hardware and what kind of cartridge you use (or even make of bullet for that cartridge.) Spend the time practing gun handling and shooting and how to read the street. That's where the real confidence builder is.