OP is looking for a caliber choice for an EAA WITNESS. Large framed full sized handgun that the FBI or any large agency wouldn't consider anyway. They are all looking for the best for the lowest common denominator. Something that will do for the least capable in the agency. Unless cost of ammo is the most important criteria for the OP, I would have to believe that the bigger bullet would be better if it can be handled effectively. I would think that if the OP is looking at a large framed heavy handgun that he most likely wouldn't feel much if any difference in handling characteristics.