Well the main reason for having a 22 mag cylinder is to have the option of having a "bigger/harder/heavier wrench in the toolbox" at your disposal, remember ballistic wise a 22 mag out of hang gun equals a 22lr out of a rifle/carbine.
Not really. From what I have seen on chrono readings the 22 mag with a 40gr bullet will get around 1500+fps from a 5.5" barreled revolver. IIRC most 40gr 22lr will be around 1200-1300fps from a rifle.
Of course you can use lighter 22 bullets from the rifle and get higher velocities but you can do the same thing with lighter weight 22 mag bullets also.
Here is an article from American Rifleman and they show just over 1400fps from a 4.5" barreled gun with Winchester 40gr ammo. I like the heavier bullets myself. And I have found the CCI 22 mag to be behind Winchester and Fiocchi in velocity. The 22 mag really benifits from a longer barreled gun.
https://www.americanrifleman.org/articles/2015/6/8/the-22-magnum-for-self-defense/
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