Yes, shoot a few groups at common defense ranges, 5yds, 7yds, and a few at 10yds too. This will teach you how it shoots relative to point of aim at those ranges. Most likely there will not be a huge difference at those ranges.
While you are doing this, you are also evaluating how the ammo functions in your pistol... If it jams or otherwise acts oddly.
On the subject of frangible rounds.
As far as penetration... The RIP rounds have shown in many tests, that the petals do not penetrate more than about 3 inches. They have been tested against simulated ribs as well, and the petals do not penetrate them. The remaining slug does not penetrate well enough either, around 10in at best.
Glasers can perform decently, and have many small wound channels out to 6-7in, and one longer channel out to about 12-13 inches. The problem is they are not consistent... For every decent performance, there is several mediocre ones. If the problems they are designed to prevent worry you, then they are better than most other frangible options.
Another frangible that performs well is the DRT... they perform pretty consistently, more so than the glasers, with decent penetration of the rear of the slug out to 12-13in, and a wide wound track out to about 6-7in.
I recommend standard hollow points whenever you can use them.