uh a revolver with a 6 round cylinder is always loaded with 5 rounds, unless you really want to risk an accidental discharge. I cannot say about the modern safeties on semi-autos, but the football player Plexico Buress shot himself in the leg with a semi-auto that was chambered and on safe and in his pocket, while dancing at a night club in NY. They locked him up for 2 years Any way I doubt there is a man on this forum that dumb as he was, but still safety is not an assurance against accidental discharge. Machines break, but an unchambered round won't accidently discharge. That said if I was expecting trouble(a cop, criminal or just in a dangerous situation) I would chamber the round!