Call it muscle memory, instinctive response, learned habit, or what you will, we all develop it to some degree, and rely on it in situations where we do not have time for conscious thought.
And it can be just the right, or just the wrong thing to do depending on the conditions.
Stepping aside from triggers for a moment, there are many people who feel a pistol with a manual safety is not for them. They are concerned that under extreme stress they will forget to take the safety off.
They lack faith in their "muscle memory" to do the right thing, every time. I understand this. I don't agree, but I understand it.
I don't see how someone would forget the safety any more than they would forget where the brake is in their car. But, apparently people do, both, so perhaps their no safety bias is right for them.
I trust my learned skills, muscle memory etc to work for me, everytime I need it. It may only be false faith, but its my faith about me, and so right for me, I think.
HOWEVER, personal experience has also taught me that the instinctive response can be the wrong response under certain conditions.
One of the most common times this can happen is when that (short) learning curve doesn't have time to become automatic. Like stepping on the clutch when the car you are in doesn't have one.
Personal story for illustration:
Friend show up, says he saw a deer up the canyon, but all he has with him is Browning 16ga auto and bird shot. Wants to borrow a rifle, go look for the deer. (in season, we're licensed, all legal, etc). I loan him deer rifle, am not all that interested in the deer. But he talks me into going with. I carry his shotgun (pheasant etc in season, too).
No deer, but on the way back pheasant flushes, lines out away, easy shot. Mount gun, punch safety off, track pull trigger. Nothing.
punch safety off again pull trigger. Nothing.
3rd time, same result, pheasant gone now.
(happened a lot faster than I can tell it)
Why did the gun not fire! My instinctive actions were exactly the right ones to have taken the bird. Exactly the right things to do, IF I had been holding my Winchester Model 12. For the Browning Auto 5, not the right things.
The point of this is that when you are at the range, or stand hunting or plinking or a number of other things, we learn and can easily switch between different guns, with different control locations, trigger pulls, etc.
BUT, when you are in a snap shot situation, hunting or self defense, those subconscious actions will only be right for ONE gun. One system. One set of control locations (safety location etc). So choose ONE system, which ever one floats your boat, and stick with it for a defense gun, so your reactions will be the right ones, when you don't have time to think about it.
DA revolver shot DA, DAO auto, no safety, DA auto w/safety SA auto w/safety, or something else pick one, focus on it. Learn it, live it, love it, as they used to say.