It depends a lot on the brand and model you buy. After reading of severl lockups on the S&W revolvers with the lock, I've decided they're not for me. Also, I won't be buying any firearm that rhymes with, say, "baurus", or "member". A lot of them are good servicable firearms (my boss carries aPT1991 as a duty weapon), but the complaints I've read and the stories told on forums concerning quality and customer service horror stories have convinced me that I dont want anything to do with them.
I will however buy a Sig, S&W, Colt, etc and run 100 rounds thru it to insure it runs correctly. I then will expect them to last 40K MINIMUM, and any major brand revolver more than that.
I understand that even Sig, HK, S&W can put out a lemon sometimes, but, you pay your money and take your choice/chance. For instance, I never bought a Yugo, even though many did. Some worked, a lot didnt. After reading the bad press on them, I never considered buying one.
Buy what will last when you start. Do your homework. I wouldn't give $50 dollars for a 1000 round handgun.