Life's a -itch, and for the most part, unless you are an off duty or undercover LEO, six should be enough, especially if they're .45's ...
Mleake's comment, "
Practice, and only one assailant.. says volumes.
Me?...I carry a J-frame Smith for the most part, with an occasional swing with
Sig's P290 8-shot 9 mm. I practice, extensively, on controlled pairs to the thoracic region from any range practicable in the real world in about 2 seconds from the holster.
Assess your threat area, work, play, live, and make a decision. For me, the weight of an "N" frame S&W, day in and day out would be excessive...and I don't carry speed loaders either...but my J-frame, M-36, with it's five shots of regular speed .38 special is enough. My wife carries a M-637 with +P ammo and we feel well armed in our area. (And no, if you're wondering, the internal lock has not presented a problem, nor have we been hit by lightning!)
Best Regards, Rod (Here are the pics...)
Sig P290, 9 mm; on duty when I'm giving my S&W M-36 a rest.
Wife's M-637, albeit with BBQ grips...it now wears Crimson Trace Lasers and resides in her purse and night stand daily.
My S&W M-36, as I carry it...enuf if you're proficient.