i think the problem here is many are posting there favorite rifle. I have favorites too but if i had to go down to only one caliber to hunt everything in the US it wouldnt be my favorite deer rifle. I think that when you factor in killing power, recoil, accuracy, cost and availability of ammo and the versitility to load it up or down for differnt applications or buy ammo for differnt applications over the counter the 06 win hands down. Theres good reason that its been the best selling rifle caliber in the country for many decades. It just plain works. 243s and 25s have there place and the mags are great for really big stuff and long range but the 06 is a gun that i can grab for ANY hunting situation and not make a mistake in my choise.