So... why are we limited to only one handgun?
That would affect my answer.
1) Just as a fun thought experiment, or whats your favorite gun kind of thing? Do I stick to picking from what I currently own, or is fantasy ok?
2) Would we be under a ownership limit, but otherwise parts and support are available?
3) Has new sales been suspended and we have to make do with the one we have, parts may or may not be available? Maybe its a SHTF scenario, but basically there is no after sale support.
Those seem to be some of the questions one would ask themselves to help answer this hypothetical.
If I pick between pistols I own, currently, I love my P266 Scorpion, and M&P9 with apex kit, I also love my CZ 75... very hard to choose for scenario 1... I would want a 22lr conversion available for versatility... So the Sig and CZ are the only choices there.
For 2... I would most likely pick the Sig, as there is manufacturing in the US, and parts support would be better overall. Lifetime warranty and all that. The CZ just doesn't have that, love it or not, if I'm limited to one, I need to be practical.
For 3... Sig again, as its more available, so spare parts would be around longer, and it is a gun that will last. (not saying the CZ isn't tough)
If I can pick any pistol, not just ones in the safe... A 22 conversion is still a must.
For 1... A higher end 1911... I don't need a pure custom job, but a nice semi custom like a Dan Wesson, or a Colt Special Combat would be very nice.
I would pick a nice 1911 for 2 as well, for the same reasons I picked the Sig before.
For 3... I would probably go with a Glock 17 or 19... the 19 having more magazine compatibility would probably make it the choice though... The reason is due to the practicality of a Glock, as well as its prevalence. If I was forced to have one pistol with unreliable support or access to replacement parts... A Glock would be hard to beat. Spare parts are more common, so the supply will last longer, and fixing problems is easier on a Glock. If I could find another busted Glock, I may be able to salvage parts. Pure practicality... Not saying a Glock will last longer or be more reliable, just easier to keep up in such a scenario...
Do I over thing these things?