Think new and innovative.
How about a polymer frame with grips that mold to your hands? Sort of like those Red Wing boot soles that you heat up, then step in to mold to your feet. How can you complain about ergos if you can pick a grip angle, then mold it to your fingers? If it held its shape, but also retained a little cushion to absorb recoil, it would be the easiest shooting pistol made.
Also, I'd love to see more pocket pistols on the market. I know they wouldn't be able to import it, but if Glock could make a .380 smaller than the G26 frame, I'd be first in line.
I'd also like to see Taurus and other low-cost manufacturers improve their quality control and reliability while retaining their lower price point. That would be good for the market overall.