Yup. 5.56 or .223 for coyotes & smaller critters, .450 Bushmaster for deer (also took it bear and pig hunting but didn't have any luck finding them due to limited opportunity in KY.)
I would depending if it was legal, depending on game and chambering. I dont, because i dont have one. But I would have no issue using the other EBR I have for hunting .308Fnar well anything deer or bigger.