Sigh. Folks, it's nice to talk all about this "what if" stuff, but it is hard to argue with years of success. For those that are new to the business, for most of the time that autoloaders have been around chamber empty was the preferred mode of carry. And strangely enough we don't find much, if any, evidence of people having problems because of it. Chamber loaded as the normal carry mode is fairly new in the game, and in fact is still frowned on by lots of people in lots of places, places that are real hot-spots where people have to use their handguns a lot. Glenn offers the only real concern issue for chamber empty, that being if your off-hand is already injured. Certain guns, certain situations, a variety of factors can all come into play. Fortunately it really doesn't matter much, adn there are advantages and disadvantages for each method of carry. The trick is finding out what works best for you.