Believe this is my first post on here so go easy on me.
I have different "best" depending on what the purpose is.
My Best field carry is a S&W 629 4" that has helped me harvest more hogs than any other firearm I own. It has also several whitetails to it's credit. It's powerful enough to drop big hogs, not so big as to be difficult to carry while riding a 4-wheeler and is smooth and accurate.
My Best for just shooting is either a S&W 617 .22lr or a Colt King Cobra, both have 4" barrels. The 617 I shoot a lot due to cheap ammo, the Colt KC is also pretty cheap to shoot since I reload. Both are accurate and very smooth with crisp, light triggers.
My Best for carry (when I carry a revolver) is a S&W 340 M&P. It's light, small, pretty smooth after a lot of dry fire and action work and offers a lot of power in a small package. I like to shoot it with some reasonable SWC reloads but I can't shoot many magnums in it. It's surprisingly accurate considering the fixed sights. The front tritium sight is easy to see both in daylight and in the dark.
Honorable mention goes to any of my Ruger single actions. My Best is probably a Blackhawk Bisley .45 convertable. It's a beast and can really throw a heavy cast bullet with authority!
As I've written this, revolvers are a lot like children: I love them all, but each for different reasons. I even could say my NAA .22 Magnum is my best (if I'm pocket carrying).