Best one? Well my Ruger FT .44 Special shoots like a dream, carries well and is about as tough as they come. I really, really like it, it's my fave to play with and carry every place I can.
BUT, my Taurus M605SS2 has proven itself through carry gun hell and back. It's covered thousands of miles on horseback, been fallen on, dunked an unknown number of times, carried in wet waders, been there while doing hay, climbing trees, cutting wood, fixing trucks, welding and on and on. And by golly when you squeeze the trigger it's still as smooth as butter and it goes bang, every time. Has never missed a beat through thousands of rounds. Plenty accurate for HD/SD and close up vermin too. It is therefore the best wheelgun I ever had (have).