I just started loading 2400 that Scoville kinda hinted around about in Handloader a 270gr SWC gc for my Uberti and Lee's flat point at about 260 using the same amount of powder in each. The bullets were picked because of the different throat diameter for each shooter. Pretty snappy, not bad accuracy and very clean except for unburnt 2400 as usual. I'm also loading a grain more with the Lee bullet for my 1873 Winchester replica. I think the wiggly Marble tang sight is keeping it from reaching its full accuracy potential. I have a barrel mounted ladder sight I will try next time. I like the .45 Colt.