Most powerful is not necessarily the best. sometimes less powerful bullets are better stoppers because more powerful ones will blow straight through the target and waste much of their energy on objects behind.
Well, except that a bullet's energy isn't what kills. Damage to internal organs is what kills. The bullet passing through those organs is what damages them, and the deeper a bullet penetrates, the more tissue and organs it's likely to damage
Also, if one uses the same bullet loaded to two different velocities, then one will have more "energy" to waste. If the faster bullet blows out the far side of a target, and "wastes" some of it's energy, then it's because it has more to waste.
The damage done by a bullet on it's way through a target has nothing to do with whether or not it has enough momentum to exit the target or not. It has far more to do with whether or not the bullet expands, and how much it expands on it's way through.
Anyway, the best round for personal defense is Federal 125 gr. JHP. This round is the gold standard of handgun stopping power. It's the round that earned the .357 its nickname "king of the streets." Use this round and you will live happily ever after.
That's a pretty bold statement, considering that bullet technology has improved drastically since the days when the .357 was "king of the streets".
I like Federal ammo just fine, but I'd hesitate to call any cartridge, bullet, or combination "best".
Daryl