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Were I to carry a .22, I would do so in a revolver so that a misfire can be addressed with another pull of the trigger.
Downside is a bad guy Bubba cranked up on coke or meth or whathaveyou who doesn't feel the pain, is intent on harming you and needs to "bleed out" whilst invoking havoc your direction.
I wasn't really addressing the power of the cartridge. However, you must admit that a cartridge that doesn't fire is even worse than an underpowered one that does. This is why, in a semi-auto, I would prefer a .25 ACP over a .22LR (even though neither gives me the warm and fuzzies).
I'm curiuous how many of you have actually had a 22 rimfire cartridge, misfire? I keep hearing these stories, about how bad they are, but I have been shooting for over 40 years, and have never had one misfire, or had any friends tell me that they have had a misfire. I'm beginning to think this is more of an urban myth, than anyting else. I'm not interested in hearsay, but only actual hands on experience. I've had plenty of misfires shooting old military cartridges, but never a 22 rimfire.
I've had several although certain brands seem to give fewer than others. The most misfire prone .22 ammo, in my experience, seems to be Remington Thunderbolts, CCI Mini Mags, CCI Stingers, Aguila Colbri, Remington Bulk "Golden Bullets", and Aguila SS Subsonic. The stuff I've had the best luck with is Federal Champion/American Eagle, Eley, and CCI Velocitors. I've experienced .22 Misfires in a variety of guns including Remington bolt and pump action rifles, Marlin and Ruger semi-auto rifles, Ruger and Browning semi-auto pistols, and High Standard, H&R, and S&W revolvers.
The reason that .22's are more prone to misfires is two-fold. First, rimfire cases are spun in a centrifuge in order to distribute the priming compound evenly. If the centrifuge is shut off too soon (a Friday night batch), the priming compound will not be evenly distributed and there will be "dead spots" around the rim. This is why when .22's misfire, rotating the round in the chamber so that the firing pin strikes a different part of the rim will often allow the round to fire. Secondly, .22 LR uses heel-based bullets which allow oil and other contaminants that can ruin the primer into the case easier than inside-lubricated bullets do. Theoretically, a .22 WMR or one of the .17 rimfires should be a bit more reliable than .22 S, L, and LR because the newer cartridges use inside-lubricated bullets.