Been loading for the 10mm since the late 80s. In the beginning I purchased bullets of all makes and weights ranging from 135 to 200gr. Initially I simply wanted to see what shot and how well.
I tested multiple powder and primer combinations and finally settled on 180gr bullets, Win-WLP, and AA-9. My pistol was a IAI Javelina with the 7" barrel. With a healthy dose of #9 it was getting me just over 1300fps. At the time Remington and Winchester bulk bullets were pretty affordable and easily had. That provided plenty of practice rounds and paved the way for the 180gr Speer Gold Dot once it was released.
Since the GD's were released I used them almost exclusively up until a few years back when I started casting. Even so, I still have hunted whitetail and feral hogs for years with lots of success. I have also added a G40 which is just as accurate and just as potent on game.
I found Accurate powder to meter great and run clean with all weights from the lighter 135's up to the 200's. I guess I'm one of those who finds what works and sticks with it. That said there have been quite a few powders come out though the years that were all the rage for several calibers including the 10mm for top end loads. Even so the Accurate line has always done well and never over worked, or over pressured brass.
Good luck with your quest, just one tidbit, don't get hung up on chasing top end velocities, stick to book loads and chase accuracy instead.