I've owned a number of Pythons. Sold them all (wish I knew that they would explode in value like they did, sigh).
The Python is a stunningly attractive gun. Exceptionally well made and, has the little pony on it. The term "bank vault lock up" had to have been coined by a Python shooter.
And, for me, growing up with Smith and Wesson, the Python has a crappy trigger. It feels like squeezing a sponge to me.
Give me a Model 27-28 or a 19-66 or a 586-686 any day.
I have nothing against Colt revolvers. My very first gun was a blued Diamondback in .22 (still have it). And, I have a Colt 1917. An OP. A SAA, and, a nickel Python.
I think if I had shot Colts as much as I shot S&W's, perhaps my opinion would be different. But, for the money, I do not think the Python is an inherently better gun than a Smith Model 27, that draws its lineage from the original 357 Magnum, the RM (or simply, The .357 Magnum)