I spent most of 30 years buying, shooting, and collecting rifles...at one time I had a few hundred rifles in just about every big game caliber you could imagine...last year I figured out what I needed and sold the rest...all of them...I now have a 30-06, a 243, an AR15, and a few 22's, and a 458 Win Mag (don't need it, just couldn't bring myself to sell it)...my wife has a 270, and a few 22's...my oldest son has a 30-06 and a 22.
As nice as it was to play with all those other rifles and calibers...
I know now that having only one rifle is NOT a handicap.
270, 280, 30-06, 308...any of those will do just fine in a one rifle battery.
The 30-06 is the one I shoot the most...but the 243 does come out once in a while for coyotes.
I took the money from selling the other rifles and bought a brand new 4x4 truck...and had plenty left for reloading supplies, hunting expenses, etc.