You won't find a .32 or .380 the size of a Bernardelli or Browning .25.
You will find the .25 has better penetration than the .22 lr.
Remember- most ballistics published for the .22 are from a rifle barrel. Even the handgun ballistics listed are usually from a 5-6" barrel.
I find it interesting that a lot of the people posting in this thread have little or no experience with the .25 acp! Of course, EVERYONE has experience with the .22- but few have experience with the .22 in a true pocket gun. The .25 seems to be viewed as an anecdotal cartridge by most people-therefore they have not studied it, and make many assumptions. They perpetuate myths, too. Perhaps they shot a cheap, worn-out .25.
Please don't misunderstand-I like all pocket guns, in any caliber. I have collected them for years.