Ok, so this is a thread back from the dead, but since it has already been resurrected, I'll chime in:
For me it isn't so much which I would choose if I couldn't have an autoloader -- I already chose, autoloader or no.
My primary SD handgun -- autoloader or not -- is my 4" 686. I would pick this over an autoloader -- any autoloader. BTW -- I really don't consider "primary" and "CCW" to be one and the same. I consider a "primary" to be more of a full-sized service handgun.
I still just don't feel as comfortable with an autoloader, there's this nagging feeling I get that there just MIGHT be a feeding failure at the worst time. I don't have that feeling with a wheelgun. I'll take my 6 reliable hard hitters and a speedloader or 2, thank you.
Ok, so if I had to use an autoloader, I'd do so (and I do, CCW/backup), but I'd still have that nagging feeling that Murphy will raise his ugly head right at the worst moment.