For a dedicated nightstand gun, I think I'd want more capacity than a single stack (10rd .45 mags are good, if you have confidence in them), and I think I'd want a light rail?
I'd prefer that the gun be a one-handed deal, so wouldn't want to have to reload, and would want my off hand available for "whatever", while accepting that a hand-held light is good.
I'm cool on night sights. I've shot in low- and no-light a bit, and while night sights are great for aiming in the dark, you shouldn't be shooting in the dark, and once you have a light on the target you don't really need night sights. I think they're great for cops or military, when whatever is "out there" is a target. For HD, target ID is top priority.
I had a hi-cap Springfield .45 with extended basepads that allowed 18+1 capacity, and I seriously considered having a rail added to the frame, but sold it, instead.