.44 Mag/spl.- BG's in your home or the better part of a football feild, game in range, bear in your tent, beer cans (if you reload, or just have to plink with something big-bore), rattlesnake curled up when you step off the trail and unzip, you name it, you're covered well. Better, I feel, than with the .38/.357, particularly in the wilderness/dangerous game department.
(Though, a 1911 in .45 with a .22 LR kit and conv. to something like .40 super may be better yet, if multiple upper ends/mags and incompatible cartridges are acceptable in covering more ground with one system, vs. one chambering)