FNX .45 would be my choice of those offered. Plenty of everything you want and a wide array of ammo choices from soft to +P. Has a rail for a light, that won't affect function and get beat up too bad.
That said, it would not be my first choice out of any handgun, but I assume it is what you own. However, what I like is not what you like. Pick the one you are the most comfortable with, shoot the best. Then get a case of ammo, maybe an advanced class and practice at least once a month.
The better your home security, the less likelihood you will need to defend with a firearm. However, the better you are with your firearms; shooting, handling and associated tactics, the better prepared you may be if you have to defend.
Who is the absolute best "situational defensive pistol" shooter you know? (Let's not debate, just think of that person). When does that person become sufficiently armed? With a .22LR, .380, 9mm, 5.56, .308? The higher the skill level, the wider the array of available weapons and calibers will be "sufficient" for 95% of the circumstances that the average civilian might be faced with. Choose accordingly.