With home defense and range use being primary, I'd opt for the CZ clone that's currently in my collection, the SAR K2-45. Excellent firearm, with the most ergonomic grip I've ever had the pleasure to grab in a high cap, 14+1, .45acp. Makes the 21SF I owned feel odd and blocky, and the FNX .45 was close, but extremely top heavy with a trigger not quite as nice as the SAR.
Now the SAR is all metal compared to the other two, and that's why it's better balanced, IMO, compared to the polymer lowers of the competition I've owned, mentioned. The weight of the SAR settles into your palm, and feels, shoots, like a much smaller handgun.
None are a bad choice, but for your intended purpose, I like the CZ idea. Of course, a nice 1911 would be a good option as well.