Glock G34, despite the fact I don't like glocks in general. Reason? Reliability, accuracy, nice enough oem trigger, and I won't hate the government too much if it is seized after being used for home defense and I have to surrender THAT pistol. Meh- it was a Glock.
Rossi 951 .38special revolver. Goes bang all the time. Accurate. Smooth trigger. .38special 'fbi special' loads are not going to give me issues with overpenetration through my wall into my neighbors' unit, and my wife or I can fire it. Also, if the revolver is seized, it was a Rossi. yes, my father in laws, but everyone was surprised he had it, so it isn't a legacy thing to my kids.
Ruger P97DC. Accurate, reliable, eats any round and wants more. Only drawback? No light rail. Advantages? Smooth trigger with light pull: DA pull under 8 lbs, SA pull under 4lbs. Oh, and not going to be out a lot of cash or stress if I have to cough it up to the DA , despite it be a legitimate and legal use of force to protect my family.
BTW, I am in california- so how it will play in the eyes of the DA is a real concern here.
There are a lot more precise firearms out there, with better reputations. Yet, these three would save either my or my wifes' life.