For Home: S&W 627 stainless "N" Frame, with a five inch barrel and full under-lug, loaded with Federal .357 magnum 158 grain Hydra-Shok rounds -- exceptionally accurate, utterly reliable, no concealment issues, and the .357 mag is still an awesomely lethal load.
For carry: Kimber Custom/Classis stainless full-sized 1911A1-type, with two ten round Wilson magazines, loaded with Federal .45 ACP 230 grain Hydra-Shok -- also exceptionally accurate, utterly reliable, packs easily, and the .45 ACP load is THE proven stopper.