Colt M1991A1 Commander 45 in the living room, Ruger P89 9 mm in the bedroom, and Beretta Tomcat 32 in my pocket or in my nightstand draw when I go to bed.
Ruger .357 revolvers with round butts so my wife can pick them up and use them. If I know bad things are going to happen I will break out the SA 1911 and Rem 870.
The 4 handguns kept in the bedroom are all .357 cal revolvers loaded with .38+P
They are kept in a quick open lock box attached to the bed frame with a cable.