Takes work
The following are just strictly personal experiences from a moderate re-loader that may or may not apply to other people's situations - no guarantees.
I only have Lee products; the LCT with Pro Auto-Disk and the the Auto Drum. From the git-go when I started reloading, I used dry graphite powder and cycled it thoroughly. There is a very thin coat inside the hoppers all the way through the riser. If I start getting inconsistencies, one of the procedures I do before continuing is recycling graphite, if I cannot determine another cause. However, I do not have to do this too often and it doesn't take long.
On the Pro Auto-disk, I use a powder check die and measure every 10th round on the scale. It has been +/- 0.1g with the majority dead on. When it gets more than that (every several months), I cycle dry graphite powder again, and it returns to normal. So far I've had consistent results regardless of various pistol powders.
The powder check die has caught no-drops. It turned out that the disk was getting stuck before reaching the fully dispense position. A thin film of dry graphite powder between the disk and the dispenser fixed that problem up. Yeah, I have dry graphite powder around ready to go. A little goes a long way.
The Auto Drum took a little more time to figure out. I've only use it on 9mm with HP-38, HS-6 and Longshot powders. As the OP stated, the problem was when the drum did not rotate the full 120 Deg, you get inconsistent (primarily less) drops. When I followed Lee's instructions EXACTLY, the problems went away. If I deviated just a little e.g. setting up the powder charging-case belling die because I wanted to minimize belling, it was a 'no-go'. I was not getting the full 120 Deg. Also a no-go was using a case previously belled, it did not get a consistent full 120 Deg. I had to carefully resize the case before going back to powder dispensing.
Now one of my checks for every drop is the full 120 degree rotation - I had to mark up the Auto drum. This is followed by a visual exam of the drop in the case. This is to check for obvious changes in the drop. Last, I measure the drop for every 5th round. So far, if there is a complete 120 deg. rotation, it does not deviate by more than +/-0.1g with most being dead on.
As mentioned before, I thoroughly ran graphite powder throughout the hopper, including the mouth that holds the hopper, all the way through the riser. I've only had to hand tighten the knob that holds the drum, and I've not had any bad leaks. Just had to make sure there is no lingering smokeless powder sticking on the drum. You want a clean interface when mating the drum to the dispenser.