.22 LR semi auto pistols are about the most "finicky" firearms that exist. Some run fine on anything, some will choke on what runs fine in other guns. They are, in general, very "selective" about what ammo feeds, and fires reliably.
AND, two different examples of exactly the same gun can have entirely different ammo preferences!!
I think the little pocket guns might be the worst of them all, for that, but don't have any real proof.
Friend of mine has a S&W model 41 the "Cadillac" of .22 Sport pistols. Great gun, feels like you're wearing a glove, you have almost be intentional to miss with it. Won't run CCI Blazer .22s. Same stuff runs through my 1983 Ruger Mk 1 Target, like water. Flawless in that gun, almost useless in a gun that doesn't like it.
If you're going to use a .22 for a back up gun, forget the most "powerful" .22s, use what is most reliable in YOUR gun, no matter what it is. If its Mini Mags, great, but even if its only standard velocity rounds, that WORK reliably, you're further ahead than using a "better" round that isn't reliable.