Since the .22 mag projectile is crimped into the case in a different manner than the .22 lr, it may be a bit more reliable in ignition than the heel crimped .22 lr but I am suspect none the less.
The kind of crimp on the bullet has nothing to do with the reliability of rimfire ignition.
Centerfires are more reliable because of the consistency of the priming system. The primer compound is in one spot, and is reliably crushed against the primer anvil (boxer priming) or the case "anvil" (Berdan priming)
Rimfire rounds are made differently. It was long ago I saw it done, but I'm pretty sure they still do it about the same way.
The case is formed, with its hollow rim, then a drop of the priming compound, as a liquid is placed inside, and the case is spun so that the liquid flows into the hollow rim by centrifugal force. Usually, this results in an even distribution of the primer compound all around the inside of the rim.
However, its not 100 percent perfect, and sometimes, gaps will happen, and if that does, AND random chance puts that "blank spot" under the firing pin when you shoot, then the round doesn't go off.
Rechambering the round so the firing pin hits a different spot on the rim nearly always results in the "bad" round firing. Additionally, since the system relies on crushing the rim against the steel of your barrel/chamber, if things are "right" in that fit, ignition problems can result. This is why rimfires are, overall, slightly less reliable than centerfires, and that difference, though small, makes them a poor choice for self defense use when it comes to firing reliably. It has nothing to do with how the bullet is held in the case.
The heel type bullet, crimped into the case is more "fragile", meaning it is more easily bent, or made loose by rough handling, which may give feeding and chambering issues, but that has nothing to do with primer ignition.
My personal "home defense" system won't work for most people, or anyone who cares about what their property looks like. Between a back injury that meant I couldn't mow my law, and a family dispute between my wife and her brother, he cut off irrigation water to my place (which I still have to pay for, though I don't get any
) my "lawn" is high desert organic, so I literally live "in the weeds" and there are several non running cars and a truck parked to serve as a barrier fence near the road. The house is in shabby shape, roof needs repair, there is no patio and no glass doors. Additionally, there is a large black dog, totally unused to anyone but us on the property, who is a mix of Australian Kelpie and I think Tasmanian devil. There is literally nothing worth stealing visible anywhere, (and damn little worth stealing inside the house).
Additionally, anyone getting past the dog would face any one (or more) of the firearms I own, or the various "decorator" swords that are within reach in most rooms of my small house.
Shotguns are good choices, though less maneuverable than a handgun. I don't consider rifles as home defense choices for inside the house. Suppressors are out (for me) simply not going to put up with the cost and legal hassle that are the current legal requirements.
Additionally, if you use a suppressed weapon for defense (which is your right, and nothing legally wrong with that) its going to be made to look really bad in court, should it come to that.
As for an "overlooked gem" for a home defense weapon, consider a medium frame .38 revolver. I prefer the S&Ws but I also have a Colt snubbie which is quite comforting to have in a pocket when things go bump in the night.
12ga coach gun inside the bedroom door, .45 auto within reach when I'm in bed. So far, so good!