I shoot single action pistols almost exclusively, so disengaging a manual safety is a subconscious act on the draw, but I have seen people draw and wonder why the gun won't fire, because they are not accustomed to disengaging a safety.
Unless you are committed to developing the required "muscle memory" via practice, you might want to go with a safety-less gun.
The manual safety is a safety in two ways; it makes your operation of the gun "safer", but if you are ever in a situation where someone else has your gun - not even necessarily an assailant, just a person who's not authorized to handle your gun - you might have some time to take appropriate action while the safety is figured-out by someone unfamiliar with your gun or its features.
Unless you are committed to developing the required "muscle memory" via practice, you might want to go with a safety-less gun.
The manual safety is a safety in two ways; it makes your operation of the gun "safer", but if you are ever in a situation where someone else has your gun - not even necessarily an assailant, just a person who's not authorized to handle your gun - you might have some time to take appropriate action while the safety is figured-out by someone unfamiliar with your gun or its features.