Are both shoulders bad? I often switch hands when doing an "arduous" task.
Also I learned a loooong time ago; there's only one way to eat an elephant, that's one bite at a time. When I'm face with a large project (sizing/depriming 300 cases), to remain pain free, I'll just do a bit of the work, one bite at a time (I continued reloading through cancer surgeries and radiation treatments) and spread the "work" out over a longer period of time.
The press choice is really personal and no one can tell you exactly what's best for you, just decide how much you can/or are willing to do. If number of handle pulls is important to you, pick a press that gives finished, safe ammo with the least number of handle movement....