I'll echo MLeake's comments about placing the gun under the thigh, between seat cushions, in a map case, etc. But for a different reason.
In the event of an accident, the gun can be dislodged under high G forces and bounce around the cabin. There is always, therefore, the potential for an AD should the impact be just right. But there's one more warning.
In the aftermath of an accident, you don't know who will be the first person(s) to gain access to your vehicle while checking your condition. In one incident, a sheriff's deputy going to work rolled his Jeep in the snow along a state highway one morning. Several cars stopped and drivers helped the deputy from his Jeep laying on its side. He never lost consciousness but in the ambulance he discovered his paddle holster and belt-clip badge carrier were missing. Police searched the area, no joy. Three months later local PD arrested a suspect in a string of armed robberies using the deputy's gun. This guy had climbed into the Jeep to support the deputy's weight while others pulled him out of the door. He spotted the badge and slipped it off, then found the gun inside the Jeep and put it in his coat pocket. No one noticed a thing.