I bought a Glock 19 gen 4 late last year, and to date is has had 16 failures to go back into battery after firing a round. All of those were my reloads, which, as it turned out, were a tad too long, which created the problem. It has been flawless using factory ammo, and since I started seating my bullets 5/1000ths of an inch deeper, it has run all of my reloads as well. My Glock has run a little over 1,000 rounds to date.
Interestingly, my Shield ran all of those rounds that my Glock could not without a hitch. My Shield has run over 1,100 rounds without a single malfunction of any kind so far.
My LCP (2nd gen) had two FTFs in the first box of 50 rounds, and has been flawless since. About 2,300 rounds through it to date.
As far as semi-autos go, so far my Beretta PX4 Storm in .40 S&W has been the most reliable gun I've ever owned. It hasn't had a single malfunction of any kind in six years, having fired more than 7,000 rounds of all manner of ammo. I even tried to torture test it a few years back by firing a minimum of 200 rounds per session doing no maintenance at all until it had a failure. I gave up trying to induce a failure after 2,800 rounds. For one session near the end I ran 450 rounds through it in one session. No issues. By 'no maintenance,' I mean that I didn't clean it, I didn't run a boresnake down the barrel, I didn't lubricate any part of it, I didn't even wipe it down. It was the Energizer Bunny; it just kept going, and going, and going . . . I finally just got bored with the exercise and also my hands were getting pretty dirty every time I picked the thing up, so I quit.
Never had any malfunctions with any of my revolvers (all Rugers and S&Ws), though I keep them pretty clean and I don't have huge round counts with them. I believe the highest round count on one of my revolvers would be my stainless GP-100, which has a little under 6,000 rounds through it, about half and half between .38 spl and .357 mag. The rest of my revolvers are all under 4,000 rounds I think. Two of them were my father's and I have no idea how many rounds he put through them before he gave them to me.
I do think Glocks are very reliable; likely in the top 5 most reliable handguns available. That said, I also believe that there are several production guns available to us now that either can give Glock a run for its money, or are flat out more reliable overall.
For myself;
Without question, if I had to choose a handgun, from my safe, to perform today, no matter what kind of ammo, and shoot all day long, I'd pick my PX4 over anything else.