I don't know I have had that question asked for a semi auto . The signs are nebulous and the highest I worked with was +p, then back off as I used factory for the normal carry and the hand loads are purely practice or back up ammo.
I did work ups with 41 magnum in some serious loads and got the sticky cases in the cylinder. Not what I normally do but I was woods cruising and fishing and it was an in case bear gun (far from the first option but as it was marginal to start with I wanted as much as I could get, ergo the 41 as it had slightly better penetration and carried 12 more rounds for it)
Mostly I hoped to get up a tree and then let it go away.
I did work ups with 41 magnum in some serious loads and got the sticky cases in the cylinder. Not what I normally do but I was woods cruising and fishing and it was an in case bear gun (far from the first option but as it was marginal to start with I wanted as much as I could get, ergo the 41 as it had slightly better penetration and carried 12 more rounds for it)
Mostly I hoped to get up a tree and then let it go away.