In the case of carrying and using a handgun for self-defense, it's not hard to imagine a scenario when having an extra toe might save your life. If the same revolver is of equal size and weight, I see no downside to one having an extra round on board when your life could be on the line in a shootout.
I'm likely older than you, Brutus, but I've never experienced any difficulty in transitioning from a six-shot revolver to one having seven shots (or going from one carrying five shots to one having six shots, for that matter). Of course, I've shot very many different types of firearms over the course of my lifetime and usually have had no problem going from one kind to another with a little practice.
And though I suppose it's "statistically" unlikely that you'll ever need more than two or three shots when using a firearm to defend your life, relying on the "odds" isn't how real life sometimes plays out. Otherwise, we might as well carry derringers.
All of which is why I prefer depending on a six-shot Colt Cobra to my five-shot J-frame Smiths and my seven-shot Model 686 Plus to a six-shot Model 686 when my life might be in jeopardy. No real downsides in size or weight in the two examples cited in exchange for getting the advantage of having an additional round in the cylinder. Whether it "seems wrong" or not.